Advancements in cancer treatment have led to a growing population of cancer survivors worldwide, who often experience premature onset of age-related conditions. Understanding the molecular and cellular basis of the long-term consequences of cancer treatment is essential for developing interventions to mitigate their adverse effects.
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References
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: An expanding universe. Cell 186, 243–278 (2022).
Kadambi, S. et al. Older adults with cancer and their caregivers - current landscape and future directions for clinical care. Nat. Rev. Clin. Oncol. 17, 742–755 (2020).
Huang, R. & Zhou, P.-K. DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy. Signal Transduct. Target. Ther. 6, 254 (2021).
Nishiyama, A. & Nakanishi, M. Navigating the DNA methylation landscape of cancer. Trends Genet. 37, 1012–1027 (2021).
Mojardín, L., Botet, J., Moreno, S. & Salas, M. Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells. Cell Cycle 14, 206–218 (2015).
Schmitt, C. A., Wang, B. & Demaria, M. Senescence and cancer - role and therapeutic opportunities. Nat. Rev. Clin. Oncol. 19, 619–636 (2022).
Demaria, M. et al. Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discov. 7, 165–176 (2017).
Murali, B. et al. Inhibition of the stromal p38MAPK/MK2 pathway limits breast cancer metastases and chemotherapy-induced bone loss. Cancer Res. 78, 5618–5630 (2018).
Guegan, M., Bichon, M., Chaput, N., Houot, R. & Lemoine, J. Cancer immunotherapy in elderly patients: The concept of immune senescence challenged by clinical experience. Eur. J. Cancer 214, 115145 (2024).
Alexandre, J. et al. Cardiovascular toxicity related to cancer treatment: a pragmatic approach to the American and European cardio-oncology guidelines. J. Am. Heart Assoc. 9, e018403 (2020).
Rao, V. et al. Chemobrain: A review on mechanistic insight, targets and treatments. Adv. Cancer Res. 155, 29–76 (2022).
Casco, S. & Soto-Vega, E. Development of metabolic syndrome associated to cancer therapy: review. Horm. Cancer 7, 289–295 (2016).
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–676 (2006).
Gowin, K. et al. Integrative therapies in cancer care: an update on the guidelines. Am. Soc. Clin. Oncol. Educ. Book 44, e431554 (2024).
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M.D. is founder and shareholder of Cleara Biotech and an advisor for Oisin Biotechnologies and Rubedo Life Sciences. The M.D. laboratory receives funding from Ono Pharmaceuticals. None of the mentioned companies contributed to this manuscript.
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Demaria, M. Cancer treatments accelerate ageing. Nat Rev Cancer 25, 751–752 (2025). https://doi.org/10.1038/s41568-025-00801-2
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DOI: https://doi.org/10.1038/s41568-025-00801-2
