Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

IMMUNOTHERAPY

TIL infusions effective in HPV-associated cancers

Nature Reviews Clinical Oncology volume 16, page 144 (2019)Cite this article

Subjects

Access through your institution
Buy or subscribe

Adoptive immunotherapy with infusion of ex vivo expanded tumour-infiltrating lymphocytes (TILs) is an attractive approach to anticancer therapy owing to the high levels of antitumour specificity that can be achieved. Now, the outcomes of a phase II study in which patients with human papillomavirus (HPV)-associated cervical (n = 18) and noncervical (n = 11) cancers reveal that this approach is feasible and is effective in some patients. TIL cultures were expanded ex vivo in the presence of tumour specimens and administered to patients as a single infusion following a nonmyeloablative chemotherapy conditioning regimen. Objective responses were observed in 28% of patients (5/18) with cervical cancer and in 18% (2/11) without. Two responses were complete and were ongoing at the time of analysis (at 67 and 53 months after infusion). The adverse event profile was consistent with that of the chemotherapy regimen: no infusion-related or autoimmune toxicities were reported.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    Peter Sidaway

Authors
  1. Peter Sidaway
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Peter Sidaway.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sidaway, P. TIL infusions effective in HPV-associated cancers. Nat Rev Clin Oncol 16, 144 (2019). https://doi.org/10.1038/s41571-018-0160-6

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41571-018-0160-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing