Table 3 Comparison of key features of engineered TCRs versus CARs
From: Harnessing the biology of regulatory T cells to treat disease
Feature | TCR | CAR |
---|---|---|
Affinity | Low | High/variable |
Co-stimulation | Exogenous | Incorporated |
Sensitivity (number of antigens required on target) | High (low antigen density) | Low (high antigen density) |
Specificity | Cross-reactive | High |
Endogenous TCR | Prone to mispairing | Independent (typically) |
Target antigens | Extracellular and intracellular | Membrane bound and oligomeric (sometimes soluble) |
Antigen type | Processed peptides | Range of possible targets |
Major histocompatibility complex | Dependent | Independent (typically) |
Immunogenicity | Unlikely | Possible |