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GENETICS

An HSD17B13 variant reduces cirrhosis risk

Nature Reviews Gastroenterology & Hepatology volume 15, page 328 (2018)Cite this article

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A newly identified gene variant reduces risk of chronic liver disease (CLD) and cirrhosis, according to a new study.

CLD and cirrhosis are important global causes of morbidity and mortality. Whereas the environmental factors contributing to the development and progression of CLD, such as alcohol and viral hepatitis, are well-understood, a large proportion of the genetic risk component is either unexplained or poorly characterized. For instance, the mechanisms underlying the association between PNPLA3 sequence variance and increased risk of NAFLD and cirrhosis remain unclear a decade after this relationship was first reported.

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References

Original article

  • Abul-Husn, N. S. et al. A protein-truncating HSD17B13 variant and protection from chronic liver disease. N. Engl. J Med. 378, 1096–1106 (2018)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Hugh Thomas

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  1. Hugh Thomas
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Correspondence to Hugh Thomas.

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Thomas, H. An HSD17B13 variant reduces cirrhosis risk. Nat Rev Gastroenterol Hepatol 15, 328 (2018). https://doi.org/10.1038/s41575-018-0016-7

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