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Folate receptor-γ in MASH-related fibrosis

Nature Reviews Gastroenterology & Hepatology volume 20, page 760 (2023)Cite this article

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A new study published in Science Translational Medicine describes the role of folate receptor-γ (FOLR3) in metabolic dysfunction-associated steatohepatitis (MASH) liver fibrogenesis. “Our research suggests further exploration of FOLR3 as a promising biomarker and potential target for therapeutic interventions,” explains corresponding author of the study Salim Merali.

Although the role of TGFβ signalling in hepatic stellate cells (HSCs) contributing to liver fibrosis was known, the specific involvement of FOLR3 in this pathway remained unclear. Comprehensive global and targeted proteomic studies found increased FOLR3 in patients with MASH, positively correlated with the fibrosis stage. When HSCs were exposed to FOLR3 treatment, secretome analysis indicated enhanced activation of HSCs via the TGFβ signalling pathway.

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Eleni Kotsiliti

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  1. Eleni Kotsiliti
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Correspondence to Eleni Kotsiliti.

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Kotsiliti, E. Folate receptor-γ in MASH-related fibrosis. Nat Rev Gastroenterol Hepatol 20, 760 (2023). https://doi.org/10.1038/s41575-023-00868-y

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