Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

MASLD

Folate receptor-γ in MASH-related fibrosis

Nature Reviews Gastroenterology & Hepatology volume 20, page 760 (2023)Cite this article

Subjects

A new study published in Science Translational Medicine describes the role of folate receptor-γ (FOLR3) in metabolic dysfunction-associated steatohepatitis (MASH) liver fibrogenesis. “Our research suggests further exploration of FOLR3 as a promising biomarker and potential target for therapeutic interventions,” explains corresponding author of the study Salim Merali.

Although the role of TGFβ signalling in hepatic stellate cells (HSCs) contributing to liver fibrosis was known, the specific involvement of FOLR3 in this pathway remained unclear. Comprehensive global and targeted proteomic studies found increased FOLR3 in patients with MASH, positively correlated with the fibrosis stage. When HSCs were exposed to FOLR3 treatment, secretome analysis indicated enhanced activation of HSCs via the TGFβ signalling pathway.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Eleni Kotsiliti

Authors
  1. Eleni Kotsiliti
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Eleni Kotsiliti.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kotsiliti, E. Folate receptor-γ in MASH-related fibrosis. Nat Rev Gastroenterol Hepatol 20, 760 (2023). https://doi.org/10.1038/s41575-023-00868-y

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41575-023-00868-y

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing