Western lifestyles cause a low-grade but chronic and metabolic inflammation (or metaflammation), which might prime committed cell lineages to initiate colon tumorigenesis. At-risk individuals might include cases of early-onset colon cancer, the incidence of which has risen dramatically in the past few decades.
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Verhagen, M.P., Schmitt, M. & Fodde, R. Western lifestyle, metaflammation and the cell of origin of colon cancer. Nat Rev Gastroenterol Hepatol 21, 603–604 (2024). https://doi.org/10.1038/s41575-024-00964-7
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DOI: https://doi.org/10.1038/s41575-024-00964-7
