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Early Crohn’s disease: can we change the disease course?

Current treatments for Crohn’s disease prioritize early intervention with biological therapies, with several landmark trials demonstrating that starting biologic agents within the first years of diagnosis leads to superior patient outcomes. Although challenges remain, early use of biological treatments is increasingly supported in managing moderate to severe Crohn’s disease.

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Correspondence to Geert D’Haens.

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D’Haens, G., Simsek, M. Early Crohn’s disease: can we change the disease course?. Nat Rev Gastroenterol Hepatol 22, 367–368 (2025). https://doi.org/10.1038/s41575-025-01072-w

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