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Submucosal electronics for long-term in situ diagnosis and therapeutics of gastrointestinal diseases

Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.

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Fig. 1: Submucosal electronics and their advantages in the gastrointestinal tract.

References

  1. Reynolds, D. et al. A leadless intracardiac transcatheter pacing system. N. Engl. J. Med. 374, 533–541 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Jansen, F. W., Kapiteyn, K., Trimbos-Kemper, T., Hermans, J. & Trimbos, J. B. Complications of laparoscopy: a prospective multicentre observational study. Br. J. Obstet. Gynaecol. 104, 595–600 (1997).

    Article  CAS  PubMed  Google Scholar 

  3. Iddan, G., Meron, G., Glukhovsky, A. & Swain, P. Wireless capsule endoscopy. Nature 405, 417 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Inoue, H. et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy 42, 265–271 (2010).

    Article  CAS  PubMed  Google Scholar 

  5. Liu, A. Q. & Chiu, P. W. Y. Third space endoscopy: current evidence and future development. Int. J. Gastrointest. Interv. 9, 42–52 (2020).

    Article  CAS  Google Scholar 

  6. Clarke, J. O. et al. An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model. Endoscopy 39, 72–76 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. Payne, S. C., Furness, J. B. & Stebbing, M. J. Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms. Nat. Rev. Gastroenterol. Hepatol. 16, 89–105 (2019).

    Article  PubMed  Google Scholar 

  8. Madhvapathy, S. R. et al. Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation. Nat. Biomed. Eng. 8, 1040–1052 (2024).

    Article  CAS  PubMed  Google Scholar 

  9. Sahasrabudhe, A. et al. Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits. Nat. Biotechnol. 42, 892–904 (2024).

    Article  CAS  PubMed  Google Scholar 

  10. Srinivasan, S. et al. Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation. Nat. Commun. 16, 7374 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Kai Fung Chan  (陳啟楓), Xianfeng Xia  (夏賢峰) or Philip Wai Yan Chiu  (趙偉仁).

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Zhang, C., Chan, K.F., Pan, C. et al. Submucosal electronics for long-term in situ diagnosis and therapeutics of gastrointestinal diseases. Nat Rev Gastroenterol Hepatol (2025). https://doi.org/10.1038/s41575-025-01130-3

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