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Make metal–organic frameworks safe and sustainable by design for industrial translation

Metal–organic frameworks hold immense application potential, but their stability and environmental safety remain barriers to industrial translation. Embracing the ‘safe and sustainable by design’ framework would, however, set a transformative pathway to the development of robust, recyclable metal–organic frameworks, ensuring functionality, minimal ecological impact and alignment with circular economy and chemical sustainability goals.

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Fig. 1: Transformation pathways of metal–organic frameworks.

References

  1. Freund, R. et al. The current status of MOF and COF applications. Angew. Chem. Int. Ed. 60, 23975–24001 (2021).

    Article  CAS  Google Scholar 

  2. Rieth, A. J., Wright, A. M. & Dincă, M. Kinetic stability of metal–organic frameworks for corrosive and coordinating gas capture. Nat. Rev. Mater. 4, 708–725 (2019).

    Article  CAS  Google Scholar 

  3. Svendsen, C. et al. Key principles and operational practices for improved nanotechnology environmental exposure assessment. Nat. Nanotechnol. 15, 731–742 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Goyal, P. et al. Fe doped bimetallic HKUST-1 MOF with enhanced water stability for trapping Pb(II) with high adsorption capacity. Chem. Eng. J. 430, 133088 (2022).

    Article  CAS  Google Scholar 

  5. Wheeler, K. E. et al. Environmental dimensions of the protein corona. Nat. Nanotechnol. 16, 617–629 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. Linnane, E., Haddad, S., Melle, F., Mei, Z. & Fairen-Jimenez, D. The uptake of metal–organic frameworks: a journey into the cell. Chem. Soc. Rev. 51, 6065–6086 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Guo, Z. et al. Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model. Proc. Natl Acad. Sci. USA 118, e2105245118 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Valsami-Jones, E. & Lynch, I. How safe are nanomaterials? Science 350, 388–389 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Dutta, S. et al. Cradle‐to‐gate environmental impact assessment of commercially available metal-organic frameworks manufacturing. Adv. Funct. Mater. https://doi.org/10.1002/adfm.202410751 (2024).

    Article  Google Scholar 

  10. Fadeel, B. et al. Advanced tools for the safety assessment of nanomaterials. Nat. Nanotechnol. 13, 537–543 (2018).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

S.C. acknowledges the UKRI – NERC Independent Research Fellowship (Grant number UKRI187) for supporting this work. D.M. acknowledges NanoDTC Cambridge – EPSRC EP/S022953/1. I.L. and S.K.M. acknowledge the Royal Society International Exchanges grant (IES\R2\232158).

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Correspondence to Swaroop Chakraborty or Iseult Lynch.

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Chakraborty, S., Menon, D., Mikulska, I. et al. Make metal–organic frameworks safe and sustainable by design for industrial translation. Nat Rev Mater 10, 167–169 (2025). https://doi.org/10.1038/s41578-025-00774-6

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