Mitigating climate change requires innovative solutions, and microorganisms, combined with artificial intelligence, can help. This Comment explores artificial intelligence strategies aimed at supporting and improving the development of microbial technologies for climate change action.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Peixoto, R. et al. Microbial solutions must be deployed against climate catastrophe. Nat. Rev. Microbiol. 23, 1–2 (2025).
Beattie, G. A. et al. Soil microbiome interventions for carbon sequestration and climate mitigation. mSystems 10, e01129-24 (2024).
Jiao, N. et al. The microbial carbon pump and climate change. Nat. Rev. Microbiol. 22, 408–419 (2024).
He, L. et al. A methanotrophic bacterium to enable methane removal for climate mitigation. Proc. Natl Acad. Sci. USA 120, e2310046120 (2023).
Hiis, E. G. et al. Unlocking bacterial potential to reduce farmland N2O emissions. Nature 630, 421–428 (2024).
Moyne, O. et al. Guild and niche determination enable targeted alteration of the microbiome. Preprint at bioRxiv https://doi.org/10.1101/2023.05.11.540389 (2023).
Bowers, R. M. et al. Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea. Nat. Biotechnol. 35, 725–731 (2018).
Arnolds, K. L. et al. Biotechnology for secure biocontainment designs in an emerging bioeconomy. Curr. Opin. Biotechnol. 71, 25–31 (2021).
Lennon, J. T. et al. Microbiology and climate change: a transdisciplinary imperative. mBio 14, e03335-22 (2023).
Landwehr, G. M. et al. Accelerated enzyme engineering by machine-learning guided cell-free expression. Nat. Commun. 16, 865 (2025).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.A.G. is on a scientific advisory board for Oath Inc. K.Z. declares no competing interests.
Rights and permissions
About this article
Cite this article
Gilbert, J.A., Zengler, K. The role of artificial intelligence in microbial sciences to support climate resilience. Nat Rev Microbiol 23, 333–334 (2025). https://doi.org/10.1038/s41579-025-01178-7
Published:
Issue date:
DOI: https://doi.org/10.1038/s41579-025-01178-7