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CELL CYCLE

Mitochondrial ROS drive cell cycle progression

Nature Reviews Molecular Cell Biology volume 23, page 581 (2022)Cite this article

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As by-products of mitochondrial respiration, reactive oxygen species (ROS) also function as signalling molecules affecting a variety of cellular processes. Previous studies indicated a stimulatory effect of low ROS levels on cell proliferation. Now, Kirova et al. provide new mechanistic insight on how ROS signals are integrated into cell cycle control through a direct interaction with cyclin-dependent kinase 2 (CDK2).

The authors found that ROS concentrations continuously increase from G1 to S and G2 phases in wild-type cells. They then identified mitochondria as the main/major source of this elevated ROS production and hypothesize that this may be due to an increase in mitochondria before cell division.

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Original article

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  • Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell. Biol. 23, 499–515 (2022)

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  • Sies, H. & Jones, D. P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat. Rev. Mol. Cell. Biol. 21, 363–383 (2020)

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  1. Associate Editor, BMC Series https://www.biomedcentral.com/

    Lisa Heinke

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  1. Lisa Heinke
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Correspondence to Lisa Heinke.

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Heinke, L. Mitochondrial ROS drive cell cycle progression. Nat Rev Mol Cell Biol 23, 581 (2022). https://doi.org/10.1038/s41580-022-00523-5

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