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Ageing

Hypoxia prevents premature ageing in mice

Nature Reviews Molecular Cell Biology volume 24, page 522 (2023)Cite this article

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Recent years have seen great progress in our understanding of the ageing process, and various approaches aimed at slowing down ageing are being actively explored. Chronic limitation of oxygen (hypoxia) prevents replicative senescence in cultured cells and extends lifespan in yeast, worms and flies. Rogers et al. now provide evidence that hypoxia is also beneficial in mammalian ageing.

To explore how hypoxia affects mammalian ageing, the authors used an Ercc1Δ/− mouse model of accelerated ageing; these mice age ~six times faster than wild-type mice owing to a deficiency in a factor involved in nucleotide excision repair. They exposed the mice to oxygen deprivation (11% oxygen) at four weeks of age, which was maintained throughout the animals’ life. Continuous exposure to hypoxia extended both mean and maximum lifespan of Ercc1Δ/− mice.

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  1. Nature Reviews Molecular Cell Biology http://www.nature.com/nrm/

    Paulina Strzyz

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  1. Paulina Strzyz
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Correspondence to Paulina Strzyz.

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Strzyz, P. Hypoxia prevents premature ageing in mice. Nat Rev Mol Cell Biol 24, 522 (2023). https://doi.org/10.1038/s41580-023-00626-7

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