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Nuclear envelope

Genome characteristics at the borders

Nature Reviews Molecular Cell Biology volume 26, page 171 (2025)Cite this article

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As the command centre of eukaryotic cells, the nucleus is partitioned from the cytoplasm by the nuclear envelope, a structure comprising a bilayer lipid membrane and the nuclear lamina — a supportive meshwork of intermediate filament proteins underlying the inner membrane. Interspersed within the nuclear envelope are the nuclear pore complexes (NPCs), which mediate nuclear–cytoplasmic transport, while also having roles in chromatin organization and gene regulation.

“… they proposed that NPC–chromatin interfaces serve as dynamic boundaries between genomic regions with different transcriptional states.”

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References

Original articles

  • Brown, C. R. et al. Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev. 22, 627–639 (2008)

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  • Guelen, L. et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature 453, 948–951 (2008)

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Related article

  • Longo, G. M. C. et al. Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils. Mol. Cell 84, 4267–4281 (2024)

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Authors and Affiliations

  1. Department of Infectious Diseases, Center for Integrative Infectious Disease Research (CIID), Integrative Virology, Heidelberg University, Heidelberg, Germany

    Marina Lusic

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  1. Marina Lusic
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Correspondence to Marina Lusic.

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Lusic, M. Genome characteristics at the borders. Nat Rev Mol Cell Biol 26, 171 (2025). https://doi.org/10.1038/s41580-024-00819-8

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  • DOI: https://doi.org/10.1038/s41580-024-00819-8

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