Disulfidptosis is an emerging form of redox-driven cell death with implications in cancer and immunity. This Comment explores gaps in our mechanistic understanding, unanswered questions, and the therapeutic potential of targeting disulfidptosis, highlighting key challenges and future directions in decoding this unique cell death pathway.
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Acknowledgements
The author thanks Q. Li and S. Wu for preparing the initial figure version. Research in the author’s laboratory has been supported, in part, by the Collaborative Accelerator for Transformative Research Endeavors grant, jointly awarded by The University of Texas at Austin and The University of Texas MD Anderson Cancer Center, and the N.G. and Helen T. Hawkins Distinguished Professorship for Cancer Research of MD Anderson Cancer Center.
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Gan, B. Redox-driven cell death by disulfidptosis and its therapeutic potential. Nat Rev Mol Cell Biol 26, 727–729 (2025). https://doi.org/10.1038/s41580-025-00888-3
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DOI: https://doi.org/10.1038/s41580-025-00888-3
