A new genome-wide association study of patients with type 1 diabetes mellitus reveals novel loci that are associated with the development of diabetic kidney disease. The most significant of these loci encodes the α3 chain of type IV collagen, which is an important component of the glomerular basement membrane.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress
Chinese Medicine Open Access 01 July 2025
-
G protein-coupled receptor 107 deficiency promotes development of diabetic nephropathy
Molecular Biomedicine Open Access 11 February 2025
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Regele, F. et al. Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes. Nephrol. Dial. Transplant. 30 (Suppl. 4), iv26–iv34 (2015).
Salem, R. M. et al. Genome-wide association study of diabetic kidney disease highlights biology involved in glomerular basement membrane collagen. J. Am. Soc. Nephrol. 30, 2000–2016 (2019).
Suh, J. H. & Miner, J. H. The glomerular basement membrane as a barrier to albumin. Nat. Rev. Nephrol. 9, 470–477 (2013).
Fioretto, P. & Mauer, M. Histopathology of diabetic nephropathy. Semin. Nephrol. 27, 195–207 (2007).
Miner, J. H. Pathology versus molecular genetics: (re)defining the spectrum of Alport syndrome. Kidney Int. 86, 1081–1083 (2014).
Kashtan, C. E. et al. Alport syndrome: a unified classification of genetic disorders of collagen IV alpha345: a position paper of the Alport Syndrome Classification Working Group. Kidney Int. 93, 1045–1051 (2018).
Savige, J. et al. Thin basement membrane nephropathy. Kidney Int. 64, 1169–1178 (2003).
Gross, O. et al. DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int. 66, 102–111 (2004).
Richter, H. et al. DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome. ACS Chem. Biol. 14, 37–49 (2019).
Gross, O. et al. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol. 29, 346–356 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.H.M. acknowledges collagen IV and diabetes-related grants from the NIH/NIDDK (R01DK078314, P30DK020579, and Diabetic Complications Consortium grants U24DK076169 and U24DK115255) and a sponsored research agreement from Reneo Pharmaceuticals.
Rights and permissions
About this article
Cite this article
Miner, J.H. Type IV collagen and diabetic kidney disease. Nat Rev Nephrol 16, 3–4 (2020). https://doi.org/10.1038/s41581-019-0229-1
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41581-019-0229-1
This article is cited by
-
Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress
Chinese Medicine (2025)
-
G protein-coupled receptor 107 deficiency promotes development of diabetic nephropathy
Molecular Biomedicine (2025)
-
Complexities of the glomerular basement membrane
Nature Reviews Nephrology (2021)
-
Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2
Journal of Natural Medicines (2021)
