Fig. 1: Pathophysiology of PO-AKI. | Nature Reviews Nephrology

Fig. 1: Pathophysiology of PO-AKI.

From: Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative

Fig. 1

Similar to most other forms of acute kidney injury (AKI), postoperative AKI (PO-AKI) commonly has a multifactorial aetiology, which is mediated by common injury pathways that affect the kidney microcirculation, oxygen demand and inflammation. In most cases, a combination of preoperative risk factors, intraoperative events and postoperative events leads to the development of AKI. Baseline risk factors and the persistence and severity of injurious factors in the postoperative setting also determine the outcomes of AKI, acute kidney disease and eventually chronic kidney disease. Adapted from Acute Disease Quality Initiative 24, www.ADQI.org, CC BY 2.0 (https://creativecommons.org/licenses/by/2.0/).

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