Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis.
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M.P.P. is conducting a trial of mega-dose vitamin C in septic shock. R.B. is coducting a trial of the physiological effect of mega-dose vitamin C in septic shock and holds intellecutal property for mega-dose vitamin C therapy in sepsis.
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NCT03654001: https://clinicaltrials.gov/ct2/show/NCT03654001
NCT03869385: https://clinicaltrials.gov/ct2/show/NCT03869385
NCT04401150: https://clinicaltrials.gov/ct2/show/NCT04401150
EudraCT 2020-003923-40: https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-003923-40/FR
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Plummer, M.P., Bellomo, R. Restrictive fluid therapy and high-dose vitamin C in sepsis. Nat Rev Nephrol 18, 607–608 (2022). https://doi.org/10.1038/s41581-022-00609-5
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DOI: https://doi.org/10.1038/s41581-022-00609-5
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Immunmodulation durch Ernährung bei kritisch kranken Patienten
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