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Glomerulonephritis

Treating AAV by targeting T cell responses

Nature Reviews Nephrology volume 20, page 770 (2024)Cite this article

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Glucocorticoids are currently used to induce remission in patients with antineutrophil cytoplasmic antibody glomerulonephritis (ANCA-GN), but these drugs carry a high risk of adverse effects and infection. Targeting T cells through cytokine inhibition might represent an alternative therapeutic approach, according to a new study by Christian Krebs, Ulf Panzer and colleagues.

A digital pharmacology analysis identified the monoclonal antibody ustekinumab, which targets IL-12 and IL-23, as a candidate treatment for targeting TH1 and TH17 cells. These T cell subsets were confirmed to be enriched in inflamed areas of the kidney in an additional cohort of patients with ANCA-GN using flow cytometry. From this cohort, four patients with relapsing disease were treated with ustekinumab, in addition to standard-of-care cyclophosphamide and steroids. Over 26 weeks, treatment led to a positive clinical and serological response without causing serious adverse effects.

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  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Monica Wang

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  1. Monica Wang
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Correspondence to Monica Wang.

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Wang, M. Treating AAV by targeting T cell responses. Nat Rev Nephrol 20, 770 (2024). https://doi.org/10.1038/s41581-024-00904-3

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  • DOI: https://doi.org/10.1038/s41581-024-00904-3

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