Innate immune memory represents a barrier to successful kidney transplantation. The discovery that uraemic toxins in people with kidney failure induce trained immunity suggests that, as chronic kidney disease progresses, long-lived memory macrophages promote systemic chronic inflammation, which could contribute to organ transplant rejection.
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J.O. is scientific founder of Trained Therapeutics Discovery. A.O. has received consultancy fees, speaker fees or travel support from Astellas, AstraZeneca, Bioporto, Boehringer Ingelheim, Fresenius Medical Care, GSK, Bayer, Sanofi-Genzyme, Sobi, Menarini, Lilly, Chiesi, Otsuka, Novo-Nordisk, Sysmex, Vifor Fresenius Medical Care Renal Pharma and Spafarma, is the Director of the Catedra UAM-AstraZeneca of chronic kidney disease and electrolytes, and has stock in Telara Farma.
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Ochando, J., Ortiz, A. Trained immunity: from kidney failure to organ transplantation. Nat Rev Nephrol 21, 224–225 (2025). https://doi.org/10.1038/s41581-024-00927-w
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DOI: https://doi.org/10.1038/s41581-024-00927-w
