The late diagnosis of chronic kidney disease (CKD) is a global problem that limits the opportunity to initiate disease-modifying therapies. Artificial intelligence approaches using imaging or laboratory-based models can facilitate the early detection and risk stratification of CKD and thereby enable optimal treatment to reduce the burden of the disease.
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References
Tangri, N. et al. Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study. BMJ Open 13, e067386 (2023).
Neuen, B. L. et al. Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal mra compared with conventional care in patients with type 2 diabetes and albuminuria. Circulation 149, 450–462 (2024).
Rajpurkar, P., Chen, E., Banerjee, O. & Topol, E. J. AI in health and medicine. Nat. Med. 28, 31–38 (2022).
Wong, C. W., Wong, T. Y., Cheng, C. Y. & Sabanayagam, C. Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways. Kidney Int. 85, 1290–1302 (2014).
Sabanayagam, C. et al. A deep learning algorithm to detect chronic kidney disease from retinal photographs in community-based populations. Lancet Digit. Health 2, e295–e302 (2020).
Betzler, B. K. et al. Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes. J. Am. Med. Inform. Assoc. 30, 1904–1914 (2023).
Zhao, X. et al. Screening chronic kidney disease through deep learning utilizing ultra-wide-field fundus images. NPJ Digit. Med. 7, 275 (2024).
Ferguson, T. et al. Development and external validation of a machine learning model for progression of CKD. Kidney Int. Rep. 7, 1772–1781 (2022).
Tangri, N. et al. Machine learning for prediction of chronic kidney disease progression: Validation of the Klinrisk model in the CANVAS program and CREDENCE trial. Diabetes Obes. Metab. 26, 3371–3380 (2024).
Tangri, N. et al. Improving the quality of CKD Care with risk prediction and personalized recommendations: 1-year results from the GEMINI-RAPA study: FR-PO1092. J. Am. Soc. Nephrol. 35 (10S), https://doi.org/10.1681/ASN.2024fzmfpmj0 (2024).
Tokita, J. et al. A real-world precision medicine program including the KidneyIntelX test effectively changes management decisions and outcomes for patients with early-stage diabetic kidney disease. J. Prim. Care Community Health https://doi.org/10.1177/21501319231223437 (2024).
Nadkarni, G. N. et al. Derivation and independent validation of kidneyintelX.dkd: a prognostic test for the assessment of diabetic kidney disease progression. Diabetes Obes. Metab. 25, 3779–3787 (2023).
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N.T. reports consultancy agreements with Marizyme, Mesentech, PulseData and Renibus; ownership interests in ClinPredict, Klinrisk, Marizyme, Mesentech, PulseData, Quanta and Renibus; receiving research funding from AstraZeneca, Bayer, BI-Lilly, Janssen and Otsuka; receiving honoraria from AstraZeneca, Bayer, BI-Lilly, Janssen, Otsuka Pharmaceuticals and Pfizer; having patents or royalties with Klinrisk and Marizyme; having an advisory or leadership role with ClinPredict and Klinrisk; other interests or relationships with the National Kidney Foundation; and being the founder of ClinPredict and Klinrisk. C.S. reports no competing interests.
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Tangri, N., Sabanayagam, C. Artificial intelligence approaches to enable early detection of CKD. Nat Rev Nephrol 21, 153–154 (2025). https://doi.org/10.1038/s41581-025-00933-6
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DOI: https://doi.org/10.1038/s41581-025-00933-6