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Oligodendrocytes — active accomplices in MS pathogenesis?

Nature Reviews Neurology volume 15, page 3 (2019)Cite this article

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Oligodendrocytes might acquire immune cell-like properties in multiple sclerosis (MS), according to new research in mice. The new findings suggest that these cells play a more active part in MS pathogenesis than previously thought.

“We were surprised to find that a subset of oligodendrocyte lineage cells, particularly oligodendrocyte precursor cells (OPCs), acquire immunological properties in MS,” explains Ana Mendanha Falcão, lead author of the new report. “Our study suggests that oligodendrocytes and OPCs are not passive targets but instead active immunomodulators of the disease.”

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Charlotte Ridler

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  1. Charlotte Ridler
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Correspondence to Charlotte Ridler.

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Ridler, C. Oligodendrocytes — active accomplices in MS pathogenesis?. Nat Rev Neurol 15, 3 (2019). https://doi.org/10.1038/s41582-018-0111-y

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