Table 2 Main components of a haematopoietic stem cell transplantation service

From: Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder — recommendations from ECTRIMS and the EBMT

Unit

Setting

Contribution to HSCT service

Neurology

Outpatient

Screening for HSCT eligibility

Pre-HSCT assessment of neurological status

Post-HSCT monitoring (focused on effectiveness outcomes)

Haematology

Outpatient and inpatient

Screening for HSCT eligibility (exclusion of contraindications)

Mobilization and collection of HSCs

Conditioning, HSC reinfusion and recovery

Post-HSCT monitoring (focused on safety outcomes, including late effects)

Neuroradiology

Outpatient

Screening for eligibility

Post-HSCT monitoring (focused on MRI outcomes)

Physiotherapy

Outpatient and inpatient

‘Pre-habilitation’

Post-HSCT rehabilitation

Laboratory

Outpatient and inpatient

Screening investigations in blood, CSF, bone marrow and other biological samples

Safety monitoring with blood biochemistries and diagnosis and monitoring of infections

Investigation of immune recovery

Reproductive medicine

Outpatient

Fertility counselling before and after HSCT

Fertility preservation

Assisted reproductive technology

Health psychology and neuropsychology

Outpatient

Psychological assessment before HSCT

Psychological counselling before and after HSCT

Neuropsychological testing before and after HSCT

Psychiatric evaluation if screening raises concerns

  1. CSF, cerebrospinal fluid; HSC, haematopoietic stem cell; HSCT, HSC transplantation.