Early adversity alters brain architecture and increases susceptibility to mental health disorders

Abstract

Each year, millions of children around the world are exposed to a host of adverse experiences early in life. These include various forms of maltreatment, growing up in unsafe neighbourhoods, and witnessing intimate partner violence. These experiences exact a toll on the brain development and mental health of children. In this Review, we attempt to explain how brain architecture and circuitry are affected by exposure to such early adversity, which in turn increases susceptibility to mental health disorders later in life. We begin defining what we mean by early adversity and then summarize the experience-dependent nature of postnatal brain development. Within this context, we discuss times in development when the brain is particularly receptive to experience (critical periods) and, thus, is more vulnerable to adverse experiences. Drawing from studies with both rodent and non-human primate models and neuroimaging research with humans, we next discuss how the circuitry of the brain is affected by early-life adversity, with a focus on the subsequent effects upon neural network development. We then review the mental health consequences of adverse experiences in early life across mental health disorders and within specific dimensions of psychopathology. We conclude by offering a conceptual model of the pathway that links exposure to adversity early in life to these mental health outcomes later in life, and we provide suggestions for future research.