The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and bottom-up mechanistic models in theoretical neuroscience, exploring how they connect with experimental practice and where there is room for future growth.
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References
Krakauer, J. W., Ghazanfar, A. A., Gomez-Marin, A., MacIver, M. A. & Poeppel, D. Neuroscience needs behavior: correcting a reductionist bias. Neuron 93, 480–490 (2017).
Datta, S. R., Anderson, D. J., Branson, K., Perona, P. & Leifer, A. Computational neuroethology: a call to action. Neuron 104, 11–24 (2019).
Anderson, D. J. & Adolphs, R. A framework for studying emotions across species. Cell 157, 187–200 (2014).
Kennedy, A. The what, how, and why of naturalistic behavior. Curr. Opin. Neurobiol. 74, 102549 (2022).
Aldarondo, D. et al. A virtual rodent predicts the structure of neural activity across behaviours. Nature 632, 594–602 (2024).
Merel, J., Botvinick, M. & Wayne, G. Hierarchical motor control in mammals and machines. Nat. Commun. 10, 5489 (2019).
Bialek, W. Emergence of brains. PRX Life 3, 037002 (2025).
Vyas, S., Golub, M. D., Sussillo, D. & Shenoy, K. V. Computation through neural population dynamics. Annu. Rev. Neurosci. 43, 249–275 (2020).
Rigotti, M. et al. The importance of mixed selectivity in complex cognitive tasks. Nature 497, 585–590 (2013).
Flavell, S. W., Gogolla, N., Lovett-Barron, M. & Zelikowsky, M. The emergence and influence of internal states. Neuron 110, 2545–2570 (2022).
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Kennedy, A. Theoretical neuroscience has room to grow. Nat. Rev. Neurosci. 26, 585–586 (2025). https://doi.org/10.1038/s41583-025-00965-8
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DOI: https://doi.org/10.1038/s41583-025-00965-8
