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Mechanisms of high-dose testosterone

Nature Reviews Urology volume 16, page 448 (2019)Cite this article

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A new study describes the characterization of the mechanisms underlying responses to supraphysiological testosterone therapy (SPT) for men with castration-resistant prostate cancer (CRPC). The findings in patient-derived xenografts (PDXs) show that SPT results in sustained suppression of AR-V7 and E2F signalling and the DNA damage response (DDR) in responders, describing potential mechanisms of tumour growth inhibition by SPT.

SPT results in sustained suppression of AR-V7 and E2F signalling and the DNA damage response

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Clemens Thoma

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  1. Clemens Thoma
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Correspondence to Clemens Thoma.

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Thoma, C. Mechanisms of high-dose testosterone. Nat Rev Urol 16, 448 (2019). https://doi.org/10.1038/s41585-019-0216-0

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