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PROSTATE CANCER

AR — the link between transcription and translation

Nature Reviews Urology volume 16, page 565 (2019)Cite this article

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The androgen receptor (AR) negatively regulates protein synthesis and low AR abundance increases translation, promoting tumour proliferation in prostate cancer, according to newly published data. This unexpected relationship revealed a druggable target for low-AR disease.

In vitro, 4EBP1 expression was considerably decreased in LNCaP cells in which AR had been eliminated. Moreover, AR and total 4EBP1 expression positively correlated in 29 LuCaP patient-derived xenografts.

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Original article

  • Liu, Y. et al. The androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Sci. Transl Med. 11, eaaw4993 (2019)

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Louise Stone

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  1. Louise Stone
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Correspondence to Louise Stone.

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Stone, L. AR — the link between transcription and translation. Nat Rev Urol 16, 565 (2019). https://doi.org/10.1038/s41585-019-0229-8

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