Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

PROSTATE CANCER

The IMPACT of BRCA2 in prostate cancer

Nature Reviews Urology volume 16, page 639 (2019)Cite this article

Subjects

Access through your institution
Buy or subscribe

Men with BRCA2 mutations are more likely be diagnosed with clinically significant prostate cancer than those without, according to new data published in European Urology. Thus, men with germline pathogenic BRCA2 mutations might benefit from systematic PSA screening.

The recently reported interim analysis included 2,932 unique individuals, comprising 919 men with BRCA1 mutations and 709 without; 902 men with BRCA2 mutations and 497 without — 95 men without BRCA2 mutations who were sequenced for both BRCA1 and BRCA2 mutations were included in both control cohorts.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Related article

  • Taylor, R. A. et al. The influence of BRCA2 mutation on localized prostate cancer. Nat. Rev. Urol. 16, 281–290 (2019)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Louise Stone

Authors
  1. Louise Stone
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Louise Stone.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stone, L. The IMPACT of BRCA2 in prostate cancer. Nat Rev Urol 16, 639 (2019). https://doi.org/10.1038/s41585-019-0249-4

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41585-019-0249-4

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer