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Quest for a genetic biomarker for sickle cell disease priapism: rationale, progress and implications

Nature Reviews Urology volume 22, pages 67–68 (2025)Cite this article

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Currently, no consensus biomarker exists for predicting priapism associated with sickle cell disease. Biochemical and haematological parameters have been investigated, but they are limited by a lack of specificity and the need for pre-validated thresholds. Genetic biomarkers are a potential alternative for further consideration in future efforts.

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Authors and Affiliations

  1. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Oluwafolajimi Adesanya & Arthur L. Burnett

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  1. Oluwafolajimi Adesanya
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  2. Arthur L. Burnett
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Correspondence to Arthur L. Burnett.

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The authors declare no competing interests.

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Adesanya, O., Burnett, A.L. Quest for a genetic biomarker for sickle cell disease priapism: rationale, progress and implications. Nat Rev Urol 22, 67–68 (2025). https://doi.org/10.1038/s41585-024-00927-2

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