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Prostate cancer

Disulfidptosis-related genes could target personalized therapy and aid prognostics

Nature Reviews Urology volume 21, page 650 (2024)Cite this article

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Disulfidptosis is a programmed cell death pathway in prostate cancer. A study in Scientific Reports has investigated the roles of genes related to disulfidptosis in disease pathogenesis and progression. The team developed a risk scoring model and then examined the relationship between this score and immune characteristics, somatic mutations and responses to therapy. Two disulfidptosis subtypes were identified: according to the risk score, the high-risk group demonstrated poorer progression-free survival and higher tumour mutational burden, associated with increased immune suppression; these high-risk features were linked to cancer pathways including IL-17 signalling. Drug sensitivity analysis suggested the potential for disulfidptosis-based personalized treatment strategies, as chemotherapy responses varied. PROK1 was identified as a prognostic marker, with reduced expression correlating with disease progression.

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References

Original article

  • Zhou, R. et al. Disulfidptosis-related genes serve as potential prognostic biomarkers and indicate tumor microenvironment characteristics and immunotherapy response in prostate cancer. Sci. Rep. 14, 14107 (2024)

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Annette Fenner

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  1. Annette Fenner
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Correspondence to Annette Fenner.

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Fenner, A. Disulfidptosis-related genes could target personalized therapy and aid prognostics. Nat Rev Urol 21, 650 (2024). https://doi.org/10.1038/s41585-024-00959-8

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  • DOI: https://doi.org/10.1038/s41585-024-00959-8

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