New evidence shows that NeuroSAFE, an intraoperative frozen section technique during radical prostatectomy, improves erectile function recovery. Traditional NeuroSAFE using frozen section analysis might not work for all centres, but new technologies for intraoperative margin assessment might facilitate more pragmatic alternatives during radical prostatectomy.
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N.L. has received reimbursement for consulting and/or speaker duty from Ferring advisory board, Device Technologies, Getz Healthcare proctoring and Astellas. D.G.M. has received reimbursement for consulting and/or speaker duty from Janssen, Bayer, Astellas, Ipsen, AstraZeneca, Novartis, Cipla, Mundipharma and Device Technologies. M.L.P. is sponsored by the Australian–American Fulbright Commission administered through a 2021–2022 Fulbright Future Scholarship funded by The Kinghorn Foundation and has received reimbursement for consulting Novartis. The other authors declare no competing interests.
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Huang, S., Chen, D.C., Hennes, D. et al. New evidence and novel techniques for assessing intraoperative margins during radical prostatectomy. Nat Rev Urol (2025). https://doi.org/10.1038/s41585-025-01087-7
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DOI: https://doi.org/10.1038/s41585-025-01087-7
