Fig. 3: Immunofluorescence analysis of viral antigens in the lungs of SARS-CoV-2-infected hACE2 mice at 3 dpi.
From: The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Colocalization of SARS-CoV-2 S protein and human ACE2 receptor in the lungs of hACE2 mice. The sections were incubated with anti-SARS-CoV-2 S protein antibody, anti-human ACE2 antibody and DAPI. a–d, Lung sections of mock-treated hACE2 mice. e–h, Lung sections of HB-01-infected hACE2 mice. White arrows show the viral S protein (f) and human ACE2 (g); yellow arrows show the merge of viral S protein and human ACE2 (h). Scale bars, 25 μm. Data in a–h are representative of three independent experiments.
