Extended Data Fig. 2: Bulk gene expression and open chromatin.

a, Heat map depicting enriched genes per tissue by bulk RNA-seq. Adjusted P ≤ 0.05, log₂(fold change) ≥ 2 (DESeq2, two-sided). Row z-scored. Top, bar plot depicting number of signature genes per tissue. b, Heat map depicting regions of open chromatin per tissue by bulk ATAC–seq. Adjusted P ≤ 0.01, log₂(fold change) ≥ 2 (DESeq2, two-sided). Row z-scored. Top, bar plot depicting number of open chromatin regions per tissue. c, Correlation (top) and BETA analysis (bottom) of bulk RNA-seq and ATAC–seq samples. d, BETA analysis of SLN evaluating enriched gene expression compared to enriched SLN OCRs. These data are representative of the rest of the dataset. e, Number of transcription factor binding motifs in signature OCRs per tissue. f, Statistical inference of transcription factor motif enrichment in fibroblasts. Bar colours denote RNA expression of transcription factor. Subcut., subcutaneous adipose; LN, lymph node.