Extended Data Fig. 8: Characterization of line attractor properties.
From: Causal evidence of a line attractor encoding an affective state
a. Average activity projected onto x1 dimension from activation of x1 neurons across mice using 8s inter stimulus interval (n = 7 mice). Shaded area – sem. Right: Quantification of average z-scored activity of projected x1 dimension during baseline or inter stimulus intervals (n = 7 mice, n.s p = 0.3, **p = 0.0012, **p = 0.0012, *p = 0.0192 Kruskal-Wallis test with Dunn’s correction for multiple comparison, error bars - sem). b. Average activity projected onto x2 dimension from activation of x2 neurons across mice using 8s inter stimulus interval (n = 7 mice). Shaded area – sem. Right: Quantification of average z-scored activity of projected x2 dimension during baseline or inter stimulus intervals (n.s p > 0.05, n = 7 mice, Kruskal-Wallis test with Dunn’s correction for multiple comparison, error bars - sem). c. Data and model prediction of applying stimulation paradigm in Fig. 2c to rSLDS model trained on observing aggression. d. Data and model prediction of applying stimulation paradigm in Fig. 2j to rSLDS model trained on observing aggression. e. x1 integration dimension activity with 1mW per neurons (blue) and 5mW per neuron (red). Shaded area – sem. n = 8 mice. f. Quantification of average z-scored activity of projected x1 dimension neurons in 1mW and 5mW per neuron during baseline or various inter stimulus intervals (n = 8 mice, *p = 0.0295, *p = 0.0186, *p = 0.045, n.s p = 0.7, Two-tailed Mann-Whitney U-test, error bars - sem). g. Paradigm for examining activity in x2 dimension upon grouped holographic activation of x1 neurons. h. Average z-score activity of neural activity projected onto x2 dimension across mice (n = 8 mice). Shaded area – sem. i. Quantification of activity in non-targeted x2 dimension upon grouped holographic activation of x1 neurons (n.s, n = 8 mice, Kruskal-Wallis test with Dunn’s correction for multiple comparison, error bars - sem). j. Paradigm for examining activity in x1 dimension upon grouped holographic activation of x2 neurons. k. Average z-score activity of neural activity projected onto x1 dimension across mice (n = 8 mice, Shaded area – sem). l. Quantification of activity in non-targeted x1 dimension upon grouped holographic activation of x2 neurons (n.s p = 0.276, n.s p = 0.276, **p = 0.0072, *p = 0.03, n = 8 mice, Kruskal-Wallis test with Dunn’s correction for multiple comparison, error bars - sem).
