Fig. 3: Neural implementation of a line attractor by functional connectivity.
From: Causal evidence of a line attractor encoding an affective state
a, Left, the paradigm for examining activity in non-targeted x1 and x2 neurons after activation of unitary x1 neurons. Right, the average z-scored activity of the perturbed (targeted) x1 neurons (25 single neurons from n = 8 mice). Data are the average trace (dark green) ± s.e.m. (shaded green area). b, The average z-scored activity of non-targeted x1 neurons after targeting unitary x1 neurons. n = 8 mice. Data are average trace (dark green) ± s.e.m. (shaded green area). c, The average z-scored activity of non-targeted x2 neurons after targeting of unitary x1 neurons. n = 8 mice. Data are average (trace in dark red) ± s.e.m. (shaded red area). d, Quantification of activity in non-targeted x1 neurons after targeting of single x1 neurons. NS, P = 0.16; **P = 0.0037 (bottom), ***P = 0.0005, **P = 0.0016 (top). n = 8 mice. Data are mean ± s.e.m. e, Quantification of the activity in non-targeted x2 neurons after targeting of single x1 neurons (NS; n = 8 mice). Data are mean ± s.e.m. f, The paradigm for examining the activity in non-targeted x1 and x2 neurons after activation of single x2 neurons (left). Right, the average z-scored activity of targeted x2 neurons (18 single neurons from n = 7 mice). Data are the average trace (dark red) ± s.e.m. (shaded red area). g, The average z-scored activity of non-targeted x2 neurons after targeting of single x2 neurons. n = 7 mice. Data are the average trace (dark red) ± s.e.m. (shaded red area). h, The average z-scored activity of non-targeted x1 neurons after targeting of single x2 neurons. n = 7 mice. Data are the average trace (dark green) ± s.e.m. (shaded green area). i, Quantification of activity in non-targeted x1 neurons after targeting of single x2 neurons. NS, from bottom to top, P = 0.999, P = 0.31, P = 0.09; *P = 0.0316. n = 7 mice. Data are mean ± s.e.m. j, Quantification of activity in non-targeted x2 neurons after targeting of single x2 neurons (NS). n = 7 mice. Data are mean ± s.e.m.
