Extended Data Fig. 3: The RpoB S491F substitution is maintained in the VREfm population.
From: Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin
a. Linear regression of root-to-tip distance as a function of sampling time. The slope is a crude estimate of the substitution rate (substitution/site) for the recombination-free SNP alignment, with the x-intercept indicative of the age of the root node and the r2 is a measure of clocklike behaviour. The x-axis is time (in years) and the y-axis displays the root-tip-divergence. The points represent an individual isolate in each cluster. b-d. Markov jump counts for the number of transitions between the binary trait of wild-type (WT) rpoB allele and RpoB S491F substitution. The number of Markov jumps for each cluster is shown on the x-axis, with the height of each bar representing the posterior probability for each individual jump.
