Extended Data Fig. 9: Crystallographic data and effect of Zn2+ on thermal stability.
From: Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation
a, Crystallographic data collection and refinement statistics. b, Purified WT or mutant AKT1 (2 µM) was treated with DMSO or compound 3 (10 µM) in the presence or absence of ZnSO4 (10 µM) for 15 min. Thermal stability (melting temperature, Tm) was assessed by differential scanning fluorimetry (mean ± s.d., n = 3). Apparently missing errors bars indicate that the error is too small to be visualized.
