Extended Data Fig. 7: Task-related activity during the sample, delay, and response epochs across task context 1, 2, and 1’.
From: A combinatorial neural code for long-term motor memory
a. Mean deconvolved activities from an example field of view across three task contexts (n = 781 neurons). b. Scatter plots and histograms of individual neuron selectivity index during the sample epoch comparing task contexts 1 and 2 (left) or task contexts 1 and 1’ (right). Colors indicate neurons with significant trial-type selectivity (P < 0.001, two-tailed t-test) during specific epochs in expert-early sessions. Neurons are colored based on their preferred trial-type in task context 1. Green, neurons preferring anterior pole position. Purple, neurons preferring posterior pole position. Gray, no preference neurons. Pearson’s correlation, task context 1 vs. 2, R = 0.8912, P = 0; task context 1 vs. 1’, R = 0.8290, P = 0. c-f. Same as Fig. 4f–i, but for activity during the sample epoch. In d and f, gray circles and lines indicate FOVs imaged across task contexts 1, 2, and 1’ (n = 24 FOVs, 5 mice); black circles and lines indicate subset of FOVs imaged across task contexts 1, 2, 1’, and 2’ (n = 5 FOVs, 2 mice). Bar/errorbar, mean/s.e.m. g-l. Same as a-f, but for activity during the delay epoch. h, red indicates neurons preferring lick left and blue indicates neurons preferring lick right in task context 1. Pearson’s correlation, task context 1 vs. 2, R = −0.1224, P = 1.38 × 10−8; task context 1 vs. 1’, R = 0.7675, P = 0. In j and l, FOVs imaged across task contexts 1, 2, and 1’ (n = 26 FOVs, 5 mice); FOVs imaged across task contexts 1, 2, 1’, and 2’ (n = 7 FOVs, 3 mice). Data from Fig. 4, replotted here for comparison. Bar/errorbar, mean/s.e.m. m-r. Same as g-l, but for activity during the response epoch. n, Pearson’s correlation, task context 1 vs. 2, R = 0.6220, P = 0; task context 1 vs. 1’, R = 0.7624, P = 0. In p and r, FOVs imaged across task contexts 1, 2, and 1’ (n = 26 FOVs, 5 mice); FOVs imaged across task contexts 1, 2, 1’, and 2’ (n = 5 FOVs, 3 mice). Bar/errorbar, mean/s.e.m.
