Fig. 3: New preparatory activity emerges by learning new task context.
From: A combinatorial neural code for long-term motor memory
a, Possible outcomes of preparatory states across different task contexts. b, Task contexts 1 and 2. Time interval between imaging sessions, 31.88 ± 13.88 days, mean ± s.d. across fields of view. c, Mean deconvolved activities from an example field of view (n = 1,112 neurons). Neurons are sorted on the basis of their selectivity during the delay epoch in either task context 1 (top) or 2 (bottom). d, Selectivity index in task context 1 (left) and 2 (right) for neurons showing significant trial-type selectivity (P < 0.001, two-tailed t-test) during the delay epoch. Red, neurons preferring lick left; blue, neurons preferring lick right. Significant selectivity and trial-type preferences are determined in task context 1. e, Schematic of movement-specific activity trajectories in activity space and CDDelay vectors across task contexts. Red and blue shading indicates preparatory states for lick left and lick right, respectively. f, ALM activities from an example field of view projected on the CDDelay from task context 1 (top) or 2 (bottom). Thick lines are the mean and thin lines show single trials. g, Decoding accuracy of the CDDelay within and across task contexts. n = 58 pairs of sessions, 10 mice. Data are mean ± s.e.m. Circles represent individual fields of view. h, Weight contribution of individual neurons to the CDDelay vectors from task contexts 1 and 2 (44,409 neurons from 10 mice).
