Extended Data Fig. 8: Effects of somatostatin on the transcriptome of excitatory neurons in the second-trimester human cortex.
From: Molecular and cellular dynamics of the developing human neocortex
a, Violin plots, box plots, barplots, and UMAP plots of several metadata of scRNA-seq datasets from organotypic human brain slice cultures treated with and without somatostatin receptor agonists, including numbers of unique molecular identifiers (# UMIs), numbers of identified genes (# genes), ages, treatments, and cell types. b, UMAP plots of cells in the scRNA-seq dataset showing the expression levels of cell-type-specific marker genes and SSTR2. c, Scatter plots illustrating the Pearson correlation of log fold changes in individual genes between Ostreotide and L-054,264 treatments. d, Gene set enrichment analysis (GSEA) highlighting the effects of L-054,264 and Ostreotide on different types of excitatory neurons. Significant terms, defined by Benjamini–Hochberg adjusted P values < 0.05, were outlined by a red circle. Abs(NES), absolute values of normalized enrichment scores.
