Extended Data Fig. 10: Cell-type-specific gene regulatory networks in the developing cortex.
From: Molecular and cellular dynamics of the developing human neocortex
a, A heatmap showing Jaccard similarity matrix of target regions of cell-type-specific eRegulons listed in Fig. 3a. b, Gene regulatory networks of selective eRegulons in RG-vRG, EN-L4-IT, IN-MGE-PV, astrocyte-protoplasmics and OPCs. TF nodes and their links to enhancers are individually coloured. The size and the transparency of the TF nodes represent their gene expression levels in each cell type. GEX, gene expression; ACC, accessibility; R2G, region-to-gene. c–f, Coverage plots showing aggregated ATAC profiles across cell types on four genomic loci—SOX6, PDGFRA, HOPX, and GAD2. Identified candidate cis-regulatory elements (cCREs) are coloured by their corresponding eRegulons. Region-to-gene links are shown as arcs and colour scaled based on region–gene importance scores obtained from SCENIC+ analysis.
