Extended Data Fig. 18: Neocortical cell association with human cognition and brain disorders.
From: Molecular and cellular dynamics of the developing human neocortex
a, UMAP plot showing the standardized per-cell SCAVENGE trait relevance score (TRS) for Alzheimer’s disease. b, Top, boxplots showing the standardized SCAVENGE TRS for Alzheimer’s disease across cell types. Boxplot centre: median; hinges: the 25th and 75th percentiles; whiskers: standard error. Bottom, bar plots showing the proportion of the cells with enriched trait relevance for Alzheimer’s disease across cell types. Two-sided hypergeometry test; *FDR < 0.01 & odds ratio > 1.4. c, Boxplots showing standardized SCAVENGE TRS for nine cognitive and disease traits across regions. Boxplot centre: median; hinges: the 25th and 75th percentiles; whiskers: standard error. Two-sided hypergeometry test; *FDR < 0.01 & odds ratio > 1.4. d, Heatmap showing the proportion of the cells with enriched trait relevance across regions. Tiles with significant TRS enrichment (two-sided hypergeometric test, *FDR < 0.01 & odds ratio > 1.4) are annotated by their odds ratios. e, Boxplots showing standardized SCAVENGE TRS for nine cognitive and disease traits across age groups. Boxplot centre: median; hinges: the 25th and 75th percentiles; whiskers: standard error. Two-sided hypergeometry test; *FDR < 0.01 & odds ratio > 1.4. f, Heatmap showing the proportion of the cells with enriched trait relevance across developmental stages. Tiles with significant TRS enrichment (two-sided hypergeometric test, *FDR < 0.01 & odds ratio > 1.4) are annotated by their odds ratios.
