Fig. 5: Cell-type association with human cognition and brain disorders.
From: Molecular and cellular dynamics of the developing human neocortex
a, Standardized per-cell SCAVENGE TRS for four cognitive functions. b, Standardized per-cell SCAVENGE TRS for five brain disorders, including ASD, MDD, BPD, ADHD and SCZ. c, The proportion of cells with enriched trait relevance across cell types. Tiles with significant TRS enrichment (two-sided hypergeometric test, *FDR-adjusted P < 0.01 and odds ratio > 1.4) are annotated by their odds ratios. d, Standardized SCAVENGE TRS of four brain disorders plotted along the IT neuron lineage pseudotime. The best-fitted smoothed lines indicate the average TRS and the 95% confidence interval in each pseudotime bin. e, Standardized gene-based AUC scores for top ten disease-relevant eRegulons (activators) ranked by Spearman’s ρ along the IT neuron lineage pseudotime. eRegulons with SFARI ASD-associated genes as core TFs are highlighted in red. For the box plots in a,b, the centre line shows the median, the box limits show the 25th and 75th percentiles, and the whiskers show the standard error. For a,b, statistical analysis was performed using two-sided hypergeometric tests; *FDR-adjusted P < 0.01 and odds ratio > 1.4.
