Extended Data Fig. 5: Cyclic amplifications are maintained in metastatic tumours.
From: Complex rearrangements fuel ER+ and HER2+ breast tumours
a-b) Number of recurrent oncogenes per Mbp for each subgroup in primary (a) and metastatic (b) tumors. c-d) Proportion of cyclic amplifications, stratified by subgroup, that amplify IC-specific or alternative oncogenes in metastatic (c) and DCIS (d) lesions. The number of amplifications in each category is included on each bar. e) Proportion of metastatic tumours within each IC subtype that harbor cyclic, complex non-cyclic or linear amplification in the IC-specific oncogenes. The number of tumors within each subtype are indicated at the top of each subpanel. f) Two representative examples of ER+ High-risk DCIS lesions harboring ecDNA containing at 8p11 (IC6). AMP, amplification.
