Fig. 2: SVs define three distinct genomic archetypes.
From: Complex rearrangements fuel ER+ and HER2+ breast tumours
a, IC group-level CNA profile (shaded area; dark denotes amplification, light denotes deletion) with SV burden (line) as overlay and total alteration burden in primary and metastatic samples. b, Pareto front projection on ternary plot of CNA and SV signature profiles from primary (left) and metastatic (right) tumours independently, resulting in three genomic archetypes. Each plotted circle represents a tumour. c, Lollipop plots illustrating the correlation between mutational features and the distance to each archetype. amp., amplification; BFB, breakage–fusion–bridge; TIC, templated insertion chain; LOH, loss of heterozygosity; WGD, whole-genome doubling; FGA, fraction of genome altered.
