Fig. 4: Complex alterations contribute to IC-specific immune escape.
From: Complex rearrangements fuel ER+ and HER2+ breast tumours
a, Schematic of TME subtypes and select immune escape pathways. b, Comparison of TME subtypes by IC subgroup. The number of tumours in each subgroup is indicated on the top of each bar. c, Left: proportion of primary and metastatic samples in each IC subgroup with GIE. Right: proportion of samples with alterations in each pathway stratified by IC subgroup and stage of progression. d, Proportion of alteration types in primary and metastatic samples for each of the immune escape pathways. The schematic in a was adapted from BioRender.com (credit: A. Iwasaki & J.-H. Lee; https://app.biorender.com/biorender-templates/figures/all/t-5f4fb77c3b02b700b74df8c6-mhc-class-i-and-ii-pathways).
