Extended Data Fig. 9: CD8 T cell-derived GZMK promotes airway eosinophil recruitment through C3.
From: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases
a-d, Induction of airway inflammation based on adoptive transfer of OT-I T cells over-expressing Gzmk, GzmkS213A (a and b) and Gzmb (c and d). a and c, Experimental setup. b and d, Numbers of indicated immune cell subsets in BALF. e-f, Asthma induction in C3-/- animals. d, Experimental schedule. e, Statistics summarizing the number of different immune cells in the BALF. Each symbol indicates one mouse, and lines denote means. Data were pooled from two (d and f) or four (b) independent experiments, with at least two animals included in each group. P values by two-sided unpaired t tests.
