Fig. 5: GZMK removal reduces inflammation and restores lung function in asthma.
From: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases
a, Experimental setup. b, Numbers of indicated immune cells in the BALF. Each symbol indicates one mouse, and lines denote means. DC, dendritic cell. c, Lung function and airway hypersensitivity in response to increasing doses of methacholine, measured by the forced oscillation technique (see Methods for more details). Each symbol indicates one mouse and bars denote means. d,e, Lung histology. d, Representative AB-PAS staining of lung tissue sections. e, PAS+ areas in the airway (see Methods for more details). Each symbol indicates one mouse, and lines denote means. Data were pooled from three independent experiments, with at least two animals included in each group. P values by two-sided unpaired t-tests. Scale bars, 100 μm. i.p., intraperitoneal; i.h., inhalation; DPI, days postimmunization.
