Extended Data Fig. 7: Chemical structures of VKs and Warfarin modeled to the VK-binding pocket in GGCX. | Nature

Extended Data Fig. 7: Chemical structures of VKs and Warfarin modeled to the VK-binding pocket in GGCX.

From: Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase

Extended Data Fig. 7

a, Structure of VK1, VK2 family and VK3. b, Warfarin modeled into the VK-binding pocket. The head group of Warfarin was aligned to that of MKO-4. The potential steric clash between GGCX and Warfarin is indicated by a dashed oval. The chemical structure of Warfarin is shown.

Back to article page