Extended Data Fig. 8: The genetic mechanisms of the palindrome-mediated translocation.

(a) The dot plots illustrate the syntenic relationship between the ancestral and duplicated copies (left panel), as well as the self-syntenic relationship of the ancestral copy (right panel). The positions of human FOLH1 and FOLH1B are highlighted with a yellow background. (b) The panel displays sequence identity heatmaps for NHPs, with the 1 Mbp flanking region of the FOLH1 q-arm, including segmental duplications (SDs) and satellite sequences shown below. Vertical lines in the identity heatmaps indicate palindromic sequences. (c) The schematic diagram describes the potential, reported DNA double-strand break repair mechanism underlying palindrome-mediated translocation. Palindromic sequences and their directions are indicated with arrows.