Extended Data Fig. 7: Inhibition efficacy of aloxistatin and the peptidomimetic inhibitors.
From: Substrate recognition and cleavage mechanism of the monkeypox virus core protease
a, Inhibiton activities of aloxistatin against MPXV CorePro and VARV CorePro, as well as compounds A1-A2 against MPXV CorePro. Each sample was tested in n = 4 biologically independent replicates and data are presented as mean values ± s.d. b, Representative curves showing VACV inhibition activity (black curves) and cell toxicity (blue curves) of aloxistatin and compounds A2-A6 in HeLa cell culture systems, and MPXV inhibition activity (black curves) and cell toxicity (blue curves) of aloxistatin in Vero-E6 cells. Data are presented as mean values ± s.d. from at least two technical repeats. EC50 values are expressed as mean values ± s.d. from at least n = 3 biologically independent replicates.
